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Niclosamide

Catalog_Number:

DB-051812

CAS:

50-65-7

Formula:

C13H8Cl2N2O4

Formula_Weight:

327.117g/mol

Purity:

95%
NOTICE: THE PRODUCT IS JUST ONLY FOR LAB RESEARCH, NOT FOR OTHER USE.
IUPAC_Name: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
InChiKey RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Synonyms:

Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-

5-Chlor-N-(2-chlor-4-nitrophenyl)-2-hydroxybenzamid

5-Chloro-N-(2-chloro-4-nitrophényl)-2-hydroxybenzamide

Canonical SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
Physical Description:

Solid

PALE, YELLOW CRYSTALS:Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 1029

Boiling Point: 424.5±45.0 °C at 760 mmHg
Melting Point: 225-230 DEG C
Flash Point: 210.5±28.7 °C
Solubility: SPARINGLY SOL IN CHLOROFORM, ETHER, ETHANOL
Stability: TABLETS ARE SENSITIVE TO MOISTURE.
Density: 1.6±0.1 g/cm3
Vapour Pressure: 0.0±1.0 mmHg at 25°C
Enthalpy of Vaporization: 70.5±3.0 kJ/mol
Index of Refraction: 1.709
Molar Refractivity: 79.0±0.3 cm3
Experimental Gravity: 210.5 g/mL
Experimental Flash Point: 210.5 °C
Experimental Solubility: DMSO <1 mg/mL; Water <1 mg/mL
Appearance: yellow solid
Vapor Pressure: <9.87X10-9 mm Hg at 20 deg C
Storage Conditions: ... stored at a temp less than 30 deg C; freezing of the tablets should be avoided.
Taste: Tasteless
Analytic Laboratory Methods: Analysis of products: As in residue analysis ... or reduction with stannous chloride, reaction with p-dimethylaminobenzaldehyde, and determination of the intensity of the yellow dye at 460 nm (R Strufe, Pflanzenschutz-Nachr Bayer 1965, 18, 130-9); or redu
Drug Indication: For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis.
Safety: GHS09
GHS Classification:
Signal: Warning
GHS Hazard Statements
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes
P264, P273, P280, P305+P351+P338, P337+P313, P391, and P501
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